Following the withdrawal of the United Kingdom from the European Union, relations between the two—the former having become a third country—are governed by a specific agreement that entered into force on 1 May 2021. Consequently, extradition procedures do not apply where the United Kingdom requests Italy to surrender a person accused of participation in a criminal association aimed at facilitating illegal immigration. In relations between the European Union and the United Kingdom of Great Britain, following the latter’s withdrawal (so-called Brexit), the European Arrest Warrant framework has been replaced—upon the entry into force of the Trade and Cooperation Agreement—by a new model of cooperation with an autonomous legal basis, namely that set out in Title VII of the said Agreement. This model provides for a system of surrender of requested persons substantially modelled on the former regime and, being self-standing, comprehensive and detailed, is directly applicable.